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Jim B.: I just looked on line and determined that while there is no reported reaction with flecainide, the anti- arrhythmic I take, there is a reaction with warfarin, the anti-coagulant I take. It seems that the fish oil may potentiate the hypoprothrombinemic effect of the warfarin. Thus, if I take too much fish oil, my INR may get too high. If I am in class and start bleeding from the ears be sure to tell me to toughen up! So far, what I am taking has not resulted in a sharp increase in my INR but I would hesitate to take a bunch more. I will see if I can get a response from my cardiologist and let you know.